Podophyllotoxin belongs to the cyclolignan family of natural products. It exhibits cathartic, cytotoxic, antimitotic,\nanticancer and other biological activities. The new podophyllotoxin analogues were synthesized in very good yields by heating\n3, 4, 5-trimethoxybenzaldehyde, succinic anhydride and amine derivatives in ethanol at 60�°C. All the products were\ncharacterized by spectral and elemental analysis data.
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